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December 10, 2009

Palmitic Acid Is a Novel CD4 Fusion Inhibitor That Blocks HIV Entry and Infection

"We investigated a large number of natural products, and from Sargassum fusiforme we isolated and identified palmitic acid (PA) as a natural small bioactive molecule with activity against HIV-1 infection. ... Understanding the structure–affinity relationship (SAR) between PA and CD4 should lead to the development of PA analogs with greater potency against HIV-1 entry."

Read more in AIDS Research and Human Retroviruses, December 9, 2009.