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January 16, 2010

New Wave of Transmitted Drug Resistance Predicted for San Francisco

"The number of new HIV infections with virus resistant to HIV drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs) could rise significantly in San Francisco and become a self-sustaining epidemic, according to a study published online January 14 in the journal Science and reported by Bloomberg News. The authors also fear that an upswing in transmitted drug-resistant virus could imperil efforts to test and treat nearly everyone living with HIV in developing countries.

"Transmitted drug resistance (TDR) is an ever-present concern for scientists, physicians and people with HIV. When people with drug-resistant HIV pass their virus to others, those newly infected people have fewer treatment options.

Thus far, TDR has remained fairly stable at about 14 percent or less of new infections in many Western countries. About 75 percent of TDR HIV cases in San Francisco involve virus resistant to NNRTIs, such as Sustiva (efavirenz) and Viramune (nevirapine)."

Read more in POZ, January 15, 2010.

Also see Evolutionary Dynamics of Complex Networks of HIV Drug-Resistant Strains: The Case of San Francisco.