HIV+ elite controllers have low HIV-specific T-cell activation yet maintain strong, polyfunctional T-cell responses

"Elite controllers maintain high levels of HIV-specific immune responses with low levels of HIV-specific T-cell activation and do not have elevated Treg cell levels. Based on these data an ideal HIV vaccine would induce strong HIV-specific immune responses whereas minimizing HIV-specific T-cell activation."

Read more: http://journals.lww.com/aidsonline/pages/articleviewer.aspx?year=2010&issue=05150&article=00003&type=abstract, May 15, 2010.