Cellular and molecular events that restrict HIV transmission identified

Physorg.com -- re article in PLoS Pathogens: "'In the absence of an effective vaccine, there is an increasing demand for the development of effective microbicides that block HIV sexual transmission. Our studies suggest that PPARγ and LXR may be targets for drugs that can simultaneously inhibit a number of aspects of HIV mucosal transmission, including inflammation, DC migration and DC-mediated HIV dissemination. Our findings therefore, provide a rationale for combining drugs that target PPARγ and LXR with conventional anti-viral microbicides that target other aspects of mucosal HIV transmission,' he added."