Establishment of HIV-1 latency in resting CD4 T cells depends on chemokine-induced changes in the actin cytoskeleton

Establishment of HIV-1 latency in resting CD4 T cells depends on chemokine-induced changes in the actin cytoskeleton — PNAS: "Eradication of HIV-1 with highly active antiretroviral therapy (HAART) is not possible due to the persistence of long-lived, latently infected resting memory CD4 T cells. We now show that HIV-1 latency can be established in resting CD4 T cells infected with HIV-1 after exposure to ligands for CCR7 (CCL19), CXCR3 (CXCL9 and CXCL10), and CCR6 (CCL20) but not in unactivated CD4 T cells. ... We propose a unique pathway for establishment of latency by direct HIV-1 infection of resting CD4+ T cells during normal chemokine-directed recirculation of CD4+ T cells between blood and tissue." [technical - relevant to cure research]