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February 16, 2011

Statins as Anti-inflammatory Therapy in HIV disease? — J Infect Dis

J Infect Dis: "The present study has additional limitations. Unfortunately, levels of inflammatory serum proteins, such as C-reactive protein, were not measured. Moreover, the duration of statin exposure was only 4 weeks, so it is not known whether the anti-inflammatory effects observed would be sustained with longer statin exposure.

"Unless other statins have modes of action that are different from those of high-dose atorvastatin, it seems unlikely that other statins will be found to suppress HIV replication. However, the present data suggest that statins merit evaluation over longer periods in HIV-infected adults who are receiving effective antiretroviral therapy but who have persistent T cell activation, given that ongoing inflammation in HIV-infected adults receiving therapy is associated with a greater risk of HIV disease progression and death. A very large study would probably be required to determine whether the potentially positive effects of statin therapy on inflammatory biomarkers will translate into less HIV disease progression and fewer cases of inflammatory non–AIDS-related illnesses, such as cardiovascular disease and end-stage liver disease."


Gidon said...

Hi there,

Just following up from my recent email about your RSS feed being published to Before It's News.

I'm the Health editor at Before It's News. Our site is a People Powered news platform with over 2,500,000 visits a month and growing fast.

We would be honored if we could republish your blog RSS feed in our Health category. Our readers need to read what your blog has to say.

Syndicating to Before It's News is a terrific way spread the word and grow your audience. Many other organizations are using Before It's News to do just that. We can have your feed up and running in 24 hours. I just need you to reply with your permission to do so. Please include the full name and email of the person who will be attached to the account, and let me know the name you want on the account (most people have their name or their blog name).

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Thank you,

Gidon Belmaker
Editor, Before It's News