AIDS Treatment News logo      

March 1, 2010

Anti-tetherin activities in Vpu-expressing primate lentiviruses

"Primate lentiviruses show a high degree of flexibility in their use of anti-tetherin factors, indicating a strong selective pressure to counteract tetherin restriction. The identification of an activity against human tetherin in SIVgsn Vpu suggests that the presence of Vpu in the ancestral SIVmus/mon/gsn virus believed to have contributed the 3' half of the HIV-1 genome may have played a role in the evolution of viruses that could counteract human tetherin and infect humans."

Read more in Retrovirology, February 18, 2010.