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September 2, 2009

Researchers identify promising agents for HIV cure research

"Researchers from the University of North Carolina and Merck are identifying promising new leads in the search for agents that may be able to purge HIV from resting CD4 cells, a key requirement for any prospect of a cure for HIV infection.

"The findings, reported by David Margolis and Nancie Archin in the September 15th edition of AIDS, show that a group of compounds called class 1 HDAC inhibitors show the most promise in activating previously latent HIV within resting CD4 cells. The findings may also explain why previous studies using another HDAC inhibitor, the antiepileptic valproic acid, showed only weak effect."

Read more in Aidsmap, September 2, 2009.