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February 24, 2010

FDA warns that saquinavir/ritonavir can cause heart rhythm disturbances

"Doctors have been advised that the use of ritonavir-boosted saquinavir should be avoided in patients with a history of prolonged QT interval, as well as by individuals treated with types of drugs that have also been associated with this complication. These include Class IA and Class III antiarrhythmic drugs such as quinidine and amiodarone.

"Individuals who are taking ritonavir-boosted saquinavir should contact their HIV doctor for advice, and not stop taking saquinavir/ritonavir until they have done so.

"Ritonavir-boosted saquinavir can have a potent anti-HIV effect when used as part of combination antiretroviral therapy. However, it is not widely used."

Read more in Aidsmap, February 24, 2010.