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June 27, 2010

Inflammation and Mortality in HIV-Infected Adults: Analysis of the FRAM Study Cohort

JAIDS Journal of Acquired Immune Deficiency Syndromes: "Conclusions: Fibrinogen and CRP are strong and independent predictors of mortality in HIV-infected adults. Our findings suggest that even in those with relatively preserved CD4 counts >500 cells per microliter, inflammation remains an important risk factor for mortality. Further investigation should determine whether interventions to reduce inflammation might decrease mortality risk in HIV-infected individuals."