AIDS Treatment News logo      

August 3, 2009

Acetylcholine-Esterase Inhibitor Pyridostigmine Decreases T Cell Overactivation in Patients Infected by HIV

"Here we showed that pyridostigmine is able to modify T cell overactivation and proliferation in patients chronically infected with HIV. Pyridostigmine led to an increase in the antiinflammatory cytokine IL-10 and a decrease in T cell proliferation and production of the proinflammatory cytokine IFN-γ."

Read more in AIDS Research and Human Retroviruses, online August 1, 2009.

Comment: This early human study could be important. The drug is approved but hazardous; it may have caused Gulf War Syndrome in the 1991 war, when it was used as protection against possible nerve-gas attack.