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August 7, 2009

A New Avenue Opens for Treating KS, CMV and Other Herpes Diseases

"After screening several dozen drugs that disrupt the development of new protease enzymes, they found several that were quite potent against Kaposi’s sarcoma–associated herpesvirus (KSHV) and CMV. “All known herpes virus proteases are structurally similar,” Craik said. “The inhibitor we found knocks out not only KS, but also the cytomegalovirus protease, so the site we’ve identified here could be a target for a broad-acting inhibitor against the entire viral family.”

"Though the drugs they found aren’t at all ready for human testing, the work of Shahian, Craik and their colleagues could pave the way for drug development that could substantially move the treatment of all herpes viruses a huge leap forward."

Read more in POZ, August 4, 2009.