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August 28, 2009

siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication

"A recent RNAi screen used a genome-wide shRNA library to search for cellular factors required for HIV-1 replication. This work complements three other siRNA-based screening studies and potentially opens the door to the discovery of factors that are important for HIV-1 replication in physiological host cells such as T lymphocytes. shRNA screens can be further improved, and they could promise to unravel new pathways and new facets of virus-cell interactions."

Read more in Retrovirology, August 27, 2009.

Comment: This technical article could be important. Both siRNA and shRNA are fairly new techniques for turning off a particular gene -- in this case for research, and potentially some day for treatment.