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August 15, 2010

Severe Symptomatic Hyperlactatemia Among HIV Type 1-Infected Adults on Antiretroviral Therapy in Côte d'Ivoire

AIDS Research and Human Retroviruses: "Stavudine is no longer recommended for use in first-line antiretroviral therapy (ART), but it remains in high demand worldwide because it is affordable. We report the clinical presentation and incidence of severe hyperlactatemia (SL) in HIV-infected adults who initiated ART between April 2005 and May 2009 in Côte d'Ivoire, West Africa. ...

"Among the eight patients with SL, 100% lost >9% of body weight before diagnosis, 100% had serum lactate >4mmol/liter (range 4.2–12.1), 50% had pre-ART BMI >25kg/m2, and three patients died (38%), accounting for 6.4% of deaths among patients taking stavudine. As long as HIV clinicians continue to use stavudine in sub-Saharan Africa, they should watch out for acute unexplained weight loss in patients taking ART, particularly among women and patients with high pre-ART BMI."