AIDS Treatment News logo      

July 12, 2009

Association of Noncirrhotic Portal Hypertension in HIV‐Infected Persons and Antiretroviral Therapy with Didanosine: A Nested Case‐Control Study

"Background.Noncirrhotic portal hypertension (NCPH) is a newly described life‐threatening liver disease of unknown cause in human immunodeficiency virus (HIV)–infected persons. Postulated pathogenesis includes prolonged exposure to antiretroviral therapy, particularly didanosine. ...

"Conclusions.We found a strong association between prolonged exposure to didanosine and the development of NCPH."

Read more in Clinical Infectious Diseases, July 9, 2009.