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October 23, 2010

Antiretroviral Drug Raltegravir May Inhibit Herpes Virus Replication "SUMMARY: Researchers in Spain have uncovered the structure of a protein complex that enables herpes viruses such as cytomegalovirus (CMV) to package their DNA into new viral particles as it replicates. As reported in the September 14, 2010 Proceedings of the National Academy of Sciences, they also found that the HIV integrase inhibitor raltegravir (Isentress) can bind to the herpes protein complex and interfere with its activity. If confirmed in future studies, raltegravir or related drugs might be active against all members of the herpes family, including the viruses that cause genital herpes simplex, shingles, and Kaposi's sarcoma."