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October 22, 2010

Guidelines for treatment of syphilis in patients with HIV have very poor evidence base

Aidsmap: "Current guidelines for the treatment of syphilis in patients with HIV are based on limited clinical data, investigators show in the online edition of Sexually Transmitted Infections.

"Even though their systematic review had broad inclusion criteria, they were only able to identify 23 studies examining the outcomes of HIV-positive patients treated for syphilis. Only two of these studies were rated as “high quality” by the investigators.

"Rates of treatment failure varied considerably, and were as high as 31% for latent syphilis. However, the investigators believe that confounding factors rather than the poor efficacy of treatment are the likely explanation for this."