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October 20, 2010

Switch from efavirenz or AZT associated with improvement in vitamin D levels

Aidsmap: "Switching antiretroviral treatment from efavirenz or AZT was associated with an improvment in vitamin D levels, investigators report in the online edition of AIDS Research and Human Retroviruses. Calendar month and black race were also associated with vitamin deficiency.

"Vitamin D levels increased significantly after patients stopped therapy with efavirenz or AZT and switched to treatment based on the protease inhibitor darunavir (Prezista) boosted by ritonavir.

"'The association between use of efavirenz and vitamin D deficiency is consistent with previous cross-sectional and prospective studies', comment the investigators. They add, 'to our knowledge, this is the first report to show rises in vitamin D levels after switching efavirenz-based antiretroviral treatment to PI [protease inhibitor]-based treatment.'"