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October 15, 2010

Inflammation and Mortality in HIV-Infected Adults: Analysis of the FRAM Study Cohort

JAIDS Journal of Acquired Immune Deficiency Syndromes: "Over a 5-year period, HIV-infected participants with fibrinogen levels in the highest tertile [highest third of the patients] (>406 mg/dL) had 2.6-fold higher adjusted odds of death than those with fibrinogen in the lowest tertile (<319 mg/dL). Those with high CRP (>3 mg/L) had 2.7-fold higher adjusted odds of death than those with CRP <1 mg/L. ...

"Conclusions: Fibrinogen and CRP are strong and independent predictors of mortality in HIV-infected adults. Our findings suggest that even in those with relatively preserved CD4 counts >500 cells per microliter, inflammation remains an important risk factor for mortality. Further investigation should determine whether interventions to reduce inflammation might decrease mortality risk in HIV-infected individuals."