Newsroom | Washington University in St. Louis: "Hruz’s lab made the discovery in mice that lacked the GLUT4 protein. When researchers gave these mice ritonavir, the drug had no effect on their glucose tolerance. However, when they gave the drug to normal mice, their blood glucose shot up very quickly, showing that the drugs impair glucose tolerance and promote insulin resistance.
“What we saw were very acute effects on insulin sensitivity that we could reverse in the mice,” Hruz says. “But when insulin resistance goes on for a long time, secondary changes develop, such as high triglycerides, and those are harder to reverse,” he says."
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