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July 2, 2010

Cellular and molecular events that restrict HIV transmission identified -- re article in PLoS Pathogens: "'In the absence of an effective vaccine, there is an increasing demand for the development of effective microbicides that block HIV sexual transmission. Our studies suggest that PPARĪ³ and LXR may be targets for drugs that can simultaneously inhibit a number of aspects of HIV mucosal transmission, including inflammation, DC migration and DC-mediated HIV dissemination. Our findings therefore, provide a rationale for combining drugs that target PPARĪ³ and LXR with conventional anti-viral microbicides that target other aspects of mucosal HIV transmission,' he added."